More Complete Arthritis Supplement

People accept arthritic disease as a 'natural part of the aging process', but sometimes the pain from osteoarthritis, rheumatoid arthritis, and over 100 other forms of arthritis so intolerable, prompting people to look for effective treatment.

Prescription drugs such as VIOXX, Bextra and Celebrex (arthritic painkillers) - and many other COX-2 inhibitors widely used for arthritic treatment - have been investigated following studies into their negative cardiovascular side effects. VIOXX alone has been linked to around 140,000 cases of coronary heart disease in the US since 1999.

More and more people look for alternative solutions for arthritis pain and more and more people are buying the combination of Glucosamine, Chondroitin Sulfate and MSN, as studies have shown that Glucosamine and Chondroitin help in the repair and maintenance of cartilage.

Both inflammation and oxidative stress function are primary degenerative mechanisms in the development and progression of osteoarthritis. While researchers believe that glucosamine inhibits inflammation and stimulates cartilage cell growth and chondroitin provides cartilage with strength and resilience, specific amino acids is also need for overall impact.

Amino acids are the building blocks that make up protein. Vitamins and minerals will not perform their specific functions effectively if the necessary amino acids are not present.

Three amino acids are critical to antioxidant, anti-inflammatory functions: cysteine, glutathione, and taurine.

Cysteine influences the synthesis of the antioxidant glutathione (GSH), which plays an important role in the inflammatory response by influencing the production of phagocytes.

Taurine acts as a specific scavenger for the hypochlorite ion, a free radical. Adequate levels of taurine naturally limit the degree of inflammation. When taurine is low, the inflammatory response is enhanced, commonly resulting in oxidative stress reactions.

Other amino acid imbalances may also impact the etiology of osteoarthritis - particularly methionine metabolism. Normally, B12 and folate are necessary for the body to metabolize homocysteine to methionine, the essential amino acid the body needs to produce S-adenosylmethionine. Numerous clinical trials have shown that S-adenosylmethionine can greatly reduce degenerative damage and symptoms of osteoarthritis in some patients, including related depression.

Imbalances of amino acids may also signal key deficiencies of vitamins and minerals integral to the musculoskeletal system. Experimental studies show that impaired cartilage structure can be induced by a vitamin B6 deficiency. Vitamin B6 triggers the transformation of the amino acid homocysteine to cystathionine and then to cysteine and its urinary metabolites.

Not all amino acids are same. Amino acids can be derived from a variety of sources, including plants, meats, fish and cartilage.

For arthritis treatment, the most compatible amino acid source is animal cartilage, including porcine, borvine cartilages and young chicken keel. Joint TLC is one of such products (www.holistictlc.com) that combines chondroitin, glucosamine and essential amino acids that promotes joint health, but this combination is still rare as most still use MSN in the place of cartilage derived amino acids, as MSN, for the marketer, is less expensive.

References:

1 Bradley JD, Flusser D, Katz BP, Schumacher HR Jr, Brandt KD, Chambers MA, Zonay LJ. A randomized, double-blind, placebo controlled trial of intravenous loading with S-adenosyltmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis. J Rheumatol 1994;21(5):905-11.

2 Barcelo HA, Wiemeyer JC, Sagasta CL, Macias M, Barreira JC. Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine. [Spanish} Rev Clin Esp 1990;187(20:74-78.

3 Konig B. A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis. Am J Med 1987;83(5A):89-94.

4 Baldessarini RJ. Neuropharmacology of S-adenosyl-L-methionine. Am J Med 1987;83(5A):95-103.

5 di Padova C. S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies. Am J Med 1987;83(5A):60-5.

6 Flynn MA, Irvin W, Krause G. The effect of folate and cobalamin on osteoarthritic hands. J Am Coll Nutr 1994;13(4):351-6.

7 McCarty MF. The neglect of glucosamine as a treatment for osteoarthritis--a personal perspective. Med Hypotheses 1994;42(5):323-7.

8 Masse PG, Ziv I, Cole DE, Mahuren JD, Donovan SM, Yamauchi M, Howell DS. A cartilage matrix deficiency experimentally induced by vitamin B6 deficiency. Proc Soc Exp Biol Med 1998;217(1):97-103.

James Well consults to nutrition industry, specializing in Diet, Energy, Libido and Diabetes care and other related holistic products. He directs a research lab facility among other projects.

Culver prom limo ..

In The News:

Fitness centers and workout studios are starting to establish policies that prohibit shooting phone videos to protect people's privacy.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents

Apple recently notified a small number of iPhone customers in 92 countries that their phones may be under attack by mercenary spyware.

An artificial intelligence-powered home security system can fire paintballs and tear gas at trespassers. The camera identifies human faces and animals.

Technology expert Kim Komando gives her tips and tricks on enhancing your user experience a smartphone and other devices you use everyday.

A new camera called NUCA uses artificial intelligence to create deepfake photos of subjects by stripping away clothing in close to real time.

The Kimberley Kube trail-ready camper has a compact but spacious design and combines luxury, functionality and ruggedness for a weekend getaway.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Emails instructing you to reset your password for an account may be legitimate, or they may be scams. Kurt "CyberGuy" Knutsson explains.

Northrop Grumman's Manta Ray uncrewed underwater vehicle aims to revolutionize undersea missions — it glides through the ocean without human assistance.

Learn how to work Google's calendar application to streamline and organize your daily tasks from technology expert Kim Komando.

If you do not want Facebook to have automatic access to your private photos, follow our tips to protect yourself. Kurt “CyberGuy" Knutsson shows you how.

Kurt “CyberGuy" Knutsson goes into detail about Apple’s recent iOS update that allows iPhone users to instantly translate spoken language simply by using the Action Button.

Safeguarding your digital life with a reliable physical backup isn't just a precaution, it's a necessity. Kurt “CyberGuy" Knutsson provides the essential backup checklist.

Kurt “CyberGuy" Knutsson reveals how a Redditor exposed false recycling claims at their apartment, highlighting a report that only 21% of U.S. recyclables are processed.

Kurt "CyberGuy" Knutsson offers a travel toolkit featuring five technology tools to help you with booking flights and hotels for your summer vacation.

The bubble behind the clock on your iPhone can appear in different colors. Kurt "CyberGuy" Knutsson explains what each of those colors mean.

Scammers are using the power of artificial intelligence to mimic voices of people and are using the fake voices to commit crimes, like kidnappings.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Tech guru Kurt "CyberGuy" Knutsson explains the science behind the Invisibility Shield, a 6-foot shield that makes people become invisible.

The International Olympic Committee on Friday announced plans to use AI in various Olympic aspects, including athlete identification, training and judging.

Tech guru Kurt "CyberGuy" Knutsson explains an easy trick to avoid squinting while working or surfing the web by zooming in on your personal computer.

Streaming giant Roku has recently been targeted by a pair of cyberattacks, and the company confirmed over a half million Roku accounts were compromised.

The Land Aircraft Carrier combines an all-terrain, six-wheeled vehicle with a two-seat aircraft, which features electric vertical takeoff and landing.

The European Union has sent TikTok a "request for information" on the video sharing platform's newest app, TikTok Lite, under the Digital Services Act, with the aim to clean up social media.

More Complete Arthritis Supplement

Nutritional Supplements